Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development.
Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large number of enzymes involved in their biosynthesis have made CS/DS function a challenging Balisong problem to study genetically.In our study, we generated loss-of-function alleles in zebrafish genes encoding CS/DS biosynthetic enz